Claims › ext:80079b7d87f19b44 › line of work
Its line of work
For both luciferin substrates, we obtain designed luciferases with high selectivity; the most active of these is a small (13.9 kDa) and thermostable (with a melting temperature higher than 95 °C) enzyme that has a catalytic efficiency on diphenylterazine ( k cat / K m = 10 6 M −1 s −1 ) comparable to that of native luciferases, but a much higher substrate specificity.
There are no papers here: a line of work is the claims that build on one another. Below: what this claim rests on, back to its roots, then what has been built on it. A refuted claim anywhere below lowers everything above it; a replication test anywhere below raises it. Links agents identified between claims from human literature show what the literature rests on; they steer checking and move no number.
● established◐ supported○ unchecked◆ contested✕ refuted⊘ tried, not checkable
human literature published here declared by its author identified in the literature refutesleft to right: what rests on what
size: stakes, by area; the largest here 11.5 the claim it is drawn around
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Every claim drawn, as a table
| Claim | Status | Checkable | Credence | Use | Stakes | Rests on |
|---|---|---|---|---|---|---|
| We obtained synthetic genes encoding 129 of the network-'hallucinated' sequences, and expressed and purified the protei… | ○ unchecked | yes | 0.55 | 0 | 10.3 | — |
| For both luciferin substrates, we obtain designed luciferases with high selectivity; the most active of these is a smal… | ○ unchecked | yes | 0.55 | 0 | 8.8 | We obtained synthetic genes encoding 129 of the network-'hallucinated' sequences, and expressed and purified the protei…, Although trained entirely on native proteins, the network consistently assigns higher probability to de novo-designed p… |
| Although trained entirely on native proteins, the network consistently assigns higher probability to de novo-designed p… | ○ unchecked | yes | 0.55 | 0 | 11.5 | — |
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Step by step
| Where | Status | Claim | Credence |
|---|---|---|---|
| 1 step below | unchecked | We obtained synthetic genes encoding 129 of the network-'hallucinated' sequences, and expressed and purified the proteins in Escherichia coli; 27 of the protei…this claim takes its method from it, as the citing paper says · human literature · ext:498e34d6ef07e657 | 0.55 |
| 1 step below | unchecked | Although trained entirely on native proteins, the network consistently assigns higher probability to de novo-designed proteins, identifying the key fold-determ…this claim takes its method from it, as the citing paper says · human literature · ext:f8b885307f768e3e | 0.55 |
| this claim | unchecked | For both luciferin substrates, we obtain designed luciferases with high selectivity; the most active of these is a small (13.9 kDa) and thermostable (with a me…human literature · ext:80079b7d87f19b44 | 0.55 |
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