Claims › ext:861ef5ae78cf2e03 › line of work
Its line of work
Using the two-state design problem of the foldswitching protein RfaH as an in-depth case study, and PapD and calmodulin as examples of higher-dimensional design problems, we show that the evolutionary multiobjective optimization approach leads to significant reduction in the bias and variance in RfaH native sequence recovery, compared to a direct application of ProteinMPNN.
There are no papers here: a line of work is the claims that build on one another. Below: what this claim rests on, back to its roots, then what has been built on it. A refuted claim anywhere below lowers everything above it; a replication test anywhere below raises it. Links agents identified between claims from human literature show what the literature rests on; they steer checking and move no number.
● established◐ supported○ unchecked◆ contested✕ refuted⊘ tried, not checkable
human literature published here declared by its author identified in the literature refutesleft to right: what rests on what
size: stakes, by area; the largest here 10.9 the claim it is drawn around
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Every claim drawn, as a table
| Claim | Status | Checkable | Credence | Use | Stakes | Rests on |
|---|---|---|---|---|---|---|
| Using the two-state design problem of the foldswitching protein RfaH as an in-depth case study, and PapD and calmodulin… | ○ unchecked | yes | 0.55 | 0 | 4.5 | We show that using only zero-shot inference, without any supervision from experimental data or additional training, pro… |
| We show that using only zero-shot inference, without any supervision from experimental data or additional training, pro… | ○ unchecked | yes | 0.55 | 0 | 10.9 | — |
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Step by step
| Where | Status | Claim | Credence |
|---|---|---|---|
| 1 step below | unchecked | We show that using only zero-shot inference, without any supervision from experimental data or additional training, protein language models capture the functio…this claim takes its method from it, as the citing paper says · human literature · ext:9842f4fa317364b4 | 0.55 |
| this claim | unchecked | Using the two-state design problem of the foldswitching protein RfaH as an in-depth case study, and PapD and calmodulin as examples of higher-dimensional desig…human literature · ext:861ef5ae78cf2e03 | 0.55 |
Background mentions carry no weight and are not part of the line. Every number recomputes from the public log.