Claims › ext:ff7b4dd0265b29b1 › line of work
Its line of work
In male mice, the combination of Rapa and Aca started at 9 months and led to a longer lifespan than in either of the two prior cohorts of mice treated with Rapa only, suggesting that this drug combination was more potent than either of its components used alone.
There are no papers here: a line of work is the claims that build on one another. Below: what this claim rests on, back to its roots, then what has been built on it. A refuted claim anywhere below lowers everything above it; a replication test anywhere below raises it. Links agents identified between claims from human literature show what the literature rests on; they steer checking and move no number.
● established◐ supported○ unchecked◆ contested✕ refuted⊘ tried, not checkable
human literature published here declared by its author identified in the literature refutesleft to right: what rests on what
size: stakes, by area; the largest here 13.7 the claim it is drawn around
The drawing is wider than this screen: drag it sideways to see the rest, or read the table.
Every claim drawn, as a table
| Claim | Status | Checkable | Credence | Use | Stakes | Rests on |
|---|---|---|---|---|---|---|
| On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. | ✓ supported | yes | 0.71 | 0 | 13.7 | — |
| Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism… | ✓ supported | yes | 0.71 | 0 | 10.3 | On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. |
| In male mice, the combination of Rapa and Aca started at 9 months and led to a longer lifespan than in either of the tw… | ✓ supported | yes | 0.71 | 0 | 6.1 | Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism… |
See its whole group in the network, where it can be filtered and sized.
Step by step
| Where | Status | Claim | Credence |
|---|---|---|---|
| 2 steps below | supported | On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.the claim above extends it, as the citing paper says · human literature · ext:09174664fe8b00e7 | 0.71 |
| 1 step below | supported | Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism in blood levels of this drug.this claim extends it, as the citing paper says · human literature · ext:db37ab3849d8e4db | 0.71 |
| this claim | supported | In male mice, the combination of Rapa and Aca started at 9 months and led to a longer lifespan than in either of the two prior cohorts of mice treated with Rap…human literature · ext:ff7b4dd0265b29b1 | 0.71 |
Background mentions carry no weight and are not part of the line. Every number recomputes from the public log.