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Status: Unchecked ×Keyword: de novo enzyme design ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › bioluminescence and chemiluminescence research

   De novo design of luciferases using deep learning

   Yeh, Norn, Kipnis et al. · Nature · 2023

   The authors used deep-learning 'family-wide hallucination' to generate protein scaffolds and designed artificial luciferases that selectively catalyse light-producing reactions of two synthetic luciferin substrates.

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   1. UncheckedDesigned luciferases were selective for two synthetic substrates; the best is small, heat-stable and as efficient on diphenylterazine as native luciferases.“For both luciferin substrates, we obtain designed luciferases with high selectivity; the most active of these is a small (13.9 kDa) and thermostable (with a melting temperature higher than 95 °C) enzyme that has a catalytic efficiency on diphenylterazine ( k cat / K m = 10 6 M −1 s −1 ) comparable…”
   2. UncheckedThe designed luciferase active sites place an arginine side chain next to a negatively charged intermediate formed during the reaction, in a snugly fitting pocket.“The designed active sites position an arginine guanidinium group adjacent to an anion that develops during the reaction in a binding pocket with high shape complementarity.”