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1,353 claims from 842 papers are on the record. 46 have been checked so far; the other 1,307 have no check with a result yet.

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Keyword: deletion mutations ×Clear all

3 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Adversarial Sequence Mutations in AlphaFold and ESMFold Reveal Nonphysical Structural Invariance, Confidence Failures, and Concerns for Protein Design

   Feldman, Brogi and Skolnick · Computational and Structural Biotechnology Journal · 2026

   Unchecked3 claims
   Show 3 claims

   1. Unchecked“Remarkably, predicted structures remain invariant to mutations of up to 40% of residues—including deliberately destabilizing substitutions—and to deletions of 10%.”
   2. Unchecked“Confidence metrics prove unreliable, as they select the most accurate structure at most 35% of the time and consistently correlate with the structural quality of the best available training-set template.”
   3. Unchecked“Notably, this invariance holds even for experimentally validated fold-switching proteins that are known to adopt alternative conformations in response to such mutations, despite the fact that these proteins are small and monomeric—precisely the category wher…