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Keyword: dihydrofolate reductase ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   GeoEvoBuilder: A deep learning framework for efficient functional and thermostable protein design

   Liu, You, Guo, Xu, Zhang and Lai · Proceedings of the National Academy of Sciences · 2025

   The paper presents GeoEvoBuilder, a deep learning tool that designs protein sequences from structural and evolutionary constraints, and reports improved activity and thermal stability in three redesigned proteins.

   Unchecked2 claims
   Show 2 claims

   1. UncheckedGeoEvoBuilder searches a wide sequence space and, in one run, produced working protein designs with more than 30% of residues changed.“Unlike conventional methods that focus on single mutation and their combinations with iterative design and experiment cycles, GeoEvoBuilder explores a large sequence space that enables successful designs with over 30% residue changes in one run.”
   2. UncheckedThe best DHFR enzyme designed by GeoEvoBuilder showed a 20-fold gain in catalytic efficiency and a 10 °C rise in thermal stability.“Notably, the top DHFR design demonstrated a 20-fold increase in catalytic efficiency and a 10 °C gain in thermal stability.”