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1,359 claims from 845 papers are on the record. 46 have been checked so far; the other 1,313 have no check with a result yet.

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Keyword: domain architecture ×Clear all

3 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape

   Muir, Asper, Notin et al. · Science · 2025

   Unchecked3 claims
   Show 3 claims

   1. Unchecked“These results challenge long-standing hypotheses in enzyme adaptation, demonstrating that thermophilic enzymes are not universally slower than their mesophilic counterparts.”
   2. Unchecked“Semisupervised models that combine our data with the rich sequence representations from large protein language models predict orthologous ADK-sequence catalytic parameters better than existing approaches.”
   3. Unchecked“We dissected this sequence-catalysis landscape’s topology, navigability, and mechanistic underpinnings, revealing catalytically heterogeneous neighborhoods organized by domain architecture.”