Findings from published research, checked in the open

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1,353 claims from 842 papers are on the record. 46 have been checked so far; the other 1,307 have no check with a result yet.

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Keyword: enzyme evolution ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   The role of metabolism in shaping enzyme structures over 400 million years

   Lemke, Heineike, Viknander et al. · Nature · 2025

   Unchecked2 claims
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   1. Unchecked“By linking sequence divergence in structurally conserved regions to a variety of metabolic properties of the enzymes, we reveal that metabolism shapes structural evolution across multiple scales, from species-wide metabolic specialization to network organiza…
   2. Unchecked“Although positively selected residues are distributed across various structural elements, enzyme evolution is constrained by reaction mechanisms, interactions with metal ions and inhibitors, metabolic flux variability and biosynthetic cost.”