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Keyword: fold switching ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Predicting multiple conformations via sequence clustering and AlphaFold2

   Wayment-Steele, Ojoawo, Otten et al. · Nature · 2023

   The authors present AF-Cluster, which clusters sequence alignments so AlphaFold2 predicts multiple protein conformations, and test its predictions on KaiB and other proteins using experiments.

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   1. UncheckedClustering the aligned sequences fed into AlphaFold2 lets it predict alternative structures of known metamorphic proteins with high confidence.“We demonstrate that clustering a multiple-sequence alignment by sequence similarity enables AlphaFold2 to sample alternative states of known metamorphic proteins with high confidence.”
   2. UncheckedNMR experiments showed a cyanobacterial KaiB variant sits in the opposite conformational state to the better-studied variant, as AF-Cluster predicted.“We used nuclear magnetic resonance spectroscopy to confirm an AF-Cluster prediction: a cyanobacteria KaiB variant is stabilized in the opposite state compared with the more widely studied variant.”