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Keyword: functional connectivity networks ×Clear all

3 claims from 1 paper

1. Neuroscience › Functional Brain Connectivity Studies

   Disrupted structural and functional brain networks in Alzheimer's disease

   Dai, Lin, Li et al. · Neurobiology of Aging · 2018

   Using two kinds of MRI in 46 patients with Alzheimer's and 39 healthy controls, the study compared functional and structural brain networks and found shared and distinct disruptions plus stronger coupling in AD.

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   1. UncheckedIn this study, brain networks of people with Alzheimer's, both functional and structural, were less integrated and less segregated than in healthy controls.“Compared with HCs, both the FCN and SCN of patients with AD showed disrupted network integration (i.e., increased characteristic path length) and segregation (i.e., decreased intramodular connections in the default mode network).”
   2. UncheckedIn this study, brain networks based on function, but not on structure, showed lower clustering and weaker rich club connections in Alzheimer's patients.“Moreover, the FCN, but not the SCN, exhibited a reduced clustering coefficient and reduced rich club connections in AD.”
   3. UncheckedIn people with Alzheimer's disease, the link between functional and structural brain networks was stronger in default mode network and rich club connections.“The coupling (i.e., correlation) of the FCN and SCN in AD was increased in connections of the default mode network and the rich club.”