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Keyword: human connectome ×Clear all

3 claims from 1 paper

1. Neuroscience › Memory and Neural Mechanisms

   A human memory circuit derived from brain lesions causing amnesia

   Ferguson, Lim, Cooke et al. · Nature Communications · 2019

   The authors derived a human memory circuit from 53 stroke case reports of amnesia plus a connectome map, and tested how well it predicts memory scores and aligns with other memory-related findings.

   Unchecked3 claims
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   1. UncheckedThe memory circuit derived from lesions causing amnesia has its central hub where the presubiculum meets the retrosplenial cortex.“Its hub is at the junction of the presubiculum and retrosplenial cortex.”
   2. UncheckedBrain regions connected to one spot, at the presubiculum–retrosplenial cortex junction, form a circuit that includes over 95% of lesions causing amnesia.“Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia.”
   3. UncheckedThe extent to which a brain lesion overlaps a derived memory circuit is reported to predict memory scores in two separate patient datasets.“Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176).”