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Status: Unchecked Keyword: influenza A virus hemagglutinin Clear all
1 claim from 1 paper
Biochemistry, Genetics and Molecular Biology › Machine Learning in Bioinformatics
Inferring context-specific site variation with evotuned protein language models
Lytras, Strange, Ito and Sato · NAR Genomics and Bioinformatics · 2026
The authors built an entropy metric from protein language model embeddings to assess site conservation and variability, and tested it on ESM-2 and protT5 models fine-tuned on influenza A hemagglutinin diversity.
Unchecked1 claimShow the claim
- UncheckedA protein language model entropy metric can flag which sites are likelier to change in a given sequence, and fine-tuning on related proteins may improve it.“Our study demonstrates how our pLM entropy metric can capture which sites are more likely to change in a specific sequence context and how fine-tuning pLMs on a set of evolutionarily related proteins (evotuning) can improve the models’ understanding of the group’s diversity.”
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