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1,248 claims from 785 papers are on the record. 45 have been checked so far; the other 1,203 have no check with a result yet.

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Status: Unchecked ×Keyword: intrinsic functional connectivity ×Clear all

4 claims from 2 papers

1. Neuroscience › Functional Brain Connectivity Studies

   Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease

   Buckner, Sepulcre, Talukdar et al. · Journal of Neuroscience · 2009

   Using brain imaging, the authors mapped highly connected cortical hubs, found them stable across task states, and noted that amyloid-β deposition in Alzheimer's disease was high at hub locations.

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   1. UncheckedIn fMRI maps of the human cortex, the most highly connected 'hub' regions lay in posterior cingulate, lateral temporal, lateral parietal and prefrontal areas.“Prominent hubs were located within posterior cingulate, lateral temporal, lateral parietal, and medial/lateral prefrontal cortices.”
   2. UncheckedIn a 12-person dataset, brain hub locations were present in both passive and active task states, which the authors take to suggest a stable feature of cortical networks.“A third dataset ( n = 12) demonstrated that the locations of hubs were present across passive and active task states, suggesting that they reflect a stable property of cortical network architecture.”
   3. UncheckedIn a small PET study, people with Alzheimer's showed more amyloid-β in cortical hub regions than older controls, which may mean hubs add to the disease process.“Positron emission tomography amyloid imaging in AD ( n = 10) compared with older controls ( n = 29) showed high amyloid-β deposition in the locations of cortical hubs consistent with the possibility that hubs, while acting as critical way stations for information processing, may also augment the un…”

2. Neuroscience › Functional Brain Connectivity Studies

   Opportunities and limitations of intrinsic functional connectivity MRI

   Buckner, Krienen and Yeo · Nature Neuroscience · 2013

   This review describes what intrinsic functional connectivity MRI can reveal about large-scale human brain networks, and the factors that complicate interpreting it.

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   1. UncheckedFunctional coupling between brain regions changes over time, which suggests anatomical connections constrain it without fully determining it.“Functional coupling changes dynamically, suggesting that it is constrained by, but not fully dictated by, anatomic connectivity.”