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1,460 claims from 908 papers are on the record. 46 have been checked so far; the other 1,414 have no check with a result yet.

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Status: Unchecked ×Keyword: intrinsically disordered regions ×Clear all

3 claims from 3 papers

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Highly accurate protein structure prediction for the human proteome

   Tunyasuvunakool, Adler, Wu et al. · Nature · 2021

   The authors applied AlphaFold 2 to almost the whole human proteome (98.5% of human proteins), greatly expanding structural coverage, and released the predictions freely.

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   1. UncheckedAlphaFold predictions for the human proteome gave a confident structure for 58% of amino-acid residues, and very high confidence for 36%.“The resulting dataset covers 58% of residues with a confident prediction, of which a subset (36% of all residues) have very high confidence.”

2. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   From interaction networks to interfaces, scanning intrinsically disordered regions using AlphaFold2

   Bret, Gao, Zea, Andréani and Guérois · Nature Communications · 2024

   The study tests AlphaFold2-Multimer on protein-peptide complexes involving disordered regions, and finds that narrowing the sequence fragments and adding evolutionary information raises success from 40% to 90%.

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   1. UncheckedWith full protein sequences, AlphaFold2-Multimer found the correct interface site and structure in only 40% of protein-peptide complexes with disordered regions.“Using a dataset of protein-peptide complexes involving intrinsically disordered regions that are non-redundant with the structures used in AlphaFold2 training, we show that when using the full sequences of the proteins, AlphaFold2-Multimer only achieves 40% success rate in identifying the correct s…”

3. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   AlphaFold-Multimer accurately captures interactions and dynamics of intrinsically disordered protein regions

   Omidi, Møller, Malhis, Bui and Gsponer · Proceedings of the National Academy of Sciences · 2024

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   1. Unchecked“Finally, our benchmarking revealed that predictions of IDR interactions can also be successful when using full-length proteins, but not as accurate as with cognate IDRs.”