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Keyword: macrocyclic peptides ×Clear all

1 claim from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   HighFold4: extending AlphaFold3 to accurate cyclic peptide conformation prediction via custom chemical connectivity

   Zhang, Wang, Zhu et al. · Briefings in Bioinformatics · 2026

   The authors adapt AlphaFold3 so users can specify the chemical bonds linking residues, aiming to predict closed-ring cyclic peptide structures with defined linkage chemistry.

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   1. UncheckedHighFold4, an adaptation of AlphaFold3 that needs no retraining, predicts diverse cyclic peptide shapes with chemistry-aware accuracy, tested on 179 structures.“Without retraining the base model, HighFold4 achieves accurate, chemistry-aware prediction of diverse cyclic peptide conformations, as validated on 179 structures.”