Findings from published research, checked in the open

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1,248 claims from 785 papers are on the record. 45 have been checked so far; the other 1,203 have no check with a result yet.

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Keyword: major depressive disorder ×Clear all

10 claims from 4 papers

1. Neuroscience › Functional Brain Connectivity Studies

   Reduced default mode network functional connectivity in patients with recurrent major depressive disorder

   Yan, Chen, Le Li et al. · Proceedings of the National Academy of Sciences · 2019

   A consortium of 25 Chinese research groups pooled resting-state brain scans from patients with major depression and controls, and found reduced default mode network connectivity, mainly in recurrent depression.

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   1. UncheckedComparing 848 patients with major depression to 794 controls from 17 sites, the study found reduced, not increased, connectivity within the default mode network.“Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion.”
   2. UncheckedIn this study, reduced connectivity within the default mode network appeared in recurrent depression but not in first-episode, drug-naïve depression.“We found FC reduction only in recurrent MDD, not in first-episode drug-naïve MDD.”
   3. UncheckedStronger connectivity within the brain's default mode network was linked to more severe depression symptoms, but only in people with recurrent major depression.“DMN FC was also positively related to symptom severity but only in recurrent MDD.”

2. Neuroscience › Functional Brain Connectivity Studies

   The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder

   Chen, Bin Lu, Li et al. · Psychoradiology · 2022

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   1. Unchecked“Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network, in whole-brain topological properties, in dynamic features, and in functional lateralization.”

3. Neuroscience › Functional Brain Connectivity Studies

   The subsystem mechanism of default mode network underlying rumination: A reproducible neuroimaging study

   Chen, Chen, Shen et al. · NeuroImage · 2020

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   1. Unchecked“During rumination, within-DMN FC was generally decreased as compared to the distraction state.”
   2. Unchecked“At the subsystem level, we found increased FC between the core and medial temporal lobe (MTL) subsystem as well as decreased FC between the core and dorsal medial prefrontal cortex (DMPFC) subsystem and within the MTL subsystem.”
   3. Unchecked“Finally, subjects' behavioral measures of rumination and brooding were negatively correlated with FC between the core and DMPFC subsystems.”

4. Neuroscience › Functional Brain Connectivity Studies

   Reproducibility of functional brain alterations in major depressive disorder: Evidence from a multisite resting-state functional MRI study with 1,434 individuals

   Xia, Si, Sun et al. · NeuroImage · 2019

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   1. Unchecked“We observed significant hypoactivity in the orbitofrontal, sensorimotor, and visual cortices and hyperactivity in the frontoparietal cortices in MDD patients compared to the controls.”
   2. Unchecked“These alterations are not affected by different statistical analysis strategies, global signal regression and medication status and are generally reproducible across centers.”
   3. Unchecked“Bootstrap analyses reveal that at least 400 subjects in each group are required to replicate significant alterations (an extent threshold of P < .05 and a height threshold of P < .001) at 50% reproducibility.”