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Status: Unchecked Keyword: nucleus basalis of Meynert Clear all
3 claims from 1 paper
Neuroscience › Functional Brain Connectivity Studies
Global fMRI signal topography differs systematically across the lifespan
Nomi, Bzdok, Li et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2022
Using a cross-sectional lifespan sample, the paper shows that how brain regions couple to the global resting-state fMRI signal follows distinct linear and curvilinear patterns across age.
Unchecked3 claimsShow 3 claims
- UncheckedIn this lifespan sample, thalamus activity is more tightly coupled to the global fMRI signal in older people, and putamen activity in younger people.“The thalamus has stronger coupling in older-age individuals compared with younger-aged individuals, while the putamen has stronger coupling in younger individuals compared with older individuals.”
- UncheckedIn a cross-sectional lifespan sample, the nucleus basalis's link to the global fMRI signal is u-shaped with age, strongest in youth and old age.“The subcortical nucleus basalis shows a u-shaped pattern similar to cortical regions within the lateral frontoparietal network and dorsal attention network, where coupling with the GS is stronger at early and old age, with weaker coupling in middle age.”
- UncheckedDifferences across the lifespan in how subcortical and cortical regions couple with the global fMRI signal support a two-layer model of that signal.“This differentiation in coupling strength between subcortical and cortical brain activity across the lifespan supports a dual-layer model of GS composition, where subcortical aspects of the GS are differentiated from cortical aspects of the GS.”
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