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Status: Unchecked ×Keyword: peptide detection ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   De novo design of high-affinity binders of bioactive helical peptides

   Torres, Leung, Venkatesh et al. · Nature · 2023

   The authors designed proteins that bind helical peptide hormones using parametric and deep-learning methods, and used RFdiffusion designs to detect parathyroid hormone and glucagon and to build biosensors.

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   1. UncheckedExtending RFdiffusion to flexible targets and adding partial diffusion yielded picomolar-affinity binders to helical peptides, including fully de novo ones.“We show that by extending RFdiffusion 8 to enable binder design to flexible targets, and to refining input structure models by successive noising and denoising (partial diffusion), picomolar-affinity binders can be generated to helical peptide targets by either refining designs generated with other…”
   2. UncheckedProtein binders designed with RFdiffusion can be used to enrich and detect parathyroid hormone and glucagon by mass spectrometry and to build bioluminescent biosensors.“The RFdiffusion designs enable the enrichment and subsequent detection of parathyroid hormone and glucagon by mass spectrometry, and the construction of bioluminescence-based protein biosensors.”