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Status: Unchecked ×Keyword: phage therapy ×Clear all

2 claims from 1 paper

1. Environmental Science › Bacteriophages and microbial interactions

   Protein structure-informed bacteriophage genome annotation with Phold

   Bouras, Grigson, Mirdita et al. · Nucleic Acids Research · 2025

   The paper presents Phold, an open-source phage genome annotation tool using protein structure information, and benchmarks it against sequence-based approaches and applies it to diverse phage genomes.

   Unchecked2 claims
   Show 2 claims

   1. UncheckedIn benchmarking, Phold, a structure-based tool, annotated phage gene functions more sensitively than sequence-based methods while staying fast, consistent and scalable.“Benchmarking reveals that Phold outperforms existing sequence-based homology approaches in functional annotation sensitivity whilst maintaining speed, consistency, and scalability.”
   2. UncheckedPhage proteins often share 3D structural similarity with proteins found across all life, especially those involved in nucleic acid metabolism and enzyme functions.“Comparisons of phage protein structures to other protein structures across the tree of life reveal that phage proteins commonly have structural homology to proteins shared across the tree of life, particularly those that have nucleic acid metabolism and enzymatic functions.”