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1,505 claims from 935 papers are on the record. 46 have been checked so far; the other 1,459 have no check with a result yet.

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Status: Unchecked ×Keyword: phosphorylation sites ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Towards a structurally resolved human protein interaction network

   Burke, Bryant, Barrio‐Hernandez et al. · Nature Structural & Molecular Biology · 2023

   The authors used AlphaFold2 to predict structures for 65,484 human protein interactions, tested how far these can be trusted, and explored what the high-confidence models reveal about disease and signalling.

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   1. UncheckedAmong 65,484 human protein interactions modelled with AlphaFold2, the authors report 3,137 high-confidence models, 1,371 with no homology to a known structure.“We identify 3,137 high-confidence models, of which 1,371 have no homology to a known structure.”
   2. UncheckedGroups of phosphorylation sites at protein interaction interfaces change together across conditions, which may reflect coordinated tuning of several interactions.“Groups of interface phosphorylation sites show patterns of co-regulation across conditions, suggestive of coordinated tuning of multiple protein interactions as signaling responses.”