Findings from published research, checked in the open

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1,353 claims from 842 papers are on the record. 46 have been checked so far; the other 1,307 have no check with a result yet.

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Keyword: presubiculum ×Clear all

6 claims from 2 papers

1. Neuroscience › Memory and Neural Mechanisms

   Grid cells in pre- and parasubiculum

   Boccara, Sargolini, Thoresen et al. · Nature Neuroscience · 2010

   In rats, grid cells were found to be abundant in pre- and parasubiculum as well as medial entorhinal cortex, alongside head-direction and border cells, which constrains how such cells might arise.

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   1. UncheckedIn rats, the share of grid cells in the pre- and parasubiculum was comparable to that in the deep layers of the medial entorhinal cortex.“The proportion of grid cells in pre- and parasubiculum was comparable to deep layers of MEC.”
   2. UncheckedIn rats, grid cells, first found in medial entorhinal cortex, were also abundant in two neighbouring brain regions, the pre- and parasubiculum.“In rats, we found that one of the cell types, the grid cell, was abundant not only in medial entorhinal cortex (MEC), where it was first reported, but also in pre- and parasubiculum.”
   3. UncheckedIn rats, grid cells in pre- and parasubiculum showed a less symmetrical grid pattern and a weaker link to theta rhythm, especially in presubiculum.“The symmetry of the grid pattern and its relationship to the theta rhythm were weaker, especially in presubiculum.”

2. Neuroscience › Memory and Neural Mechanisms

   A human memory circuit derived from brain lesions causing amnesia

   Ferguson, Lim, Cooke et al. · Nature Communications · 2019

   The authors derived a human memory circuit from 53 stroke case reports of amnesia plus a connectome map, and tested how well it predicts memory scores and aligns with other memory-related findings.

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   1. UncheckedThe memory circuit derived from lesions causing amnesia has its central hub where the presubiculum meets the retrosplenial cortex.“Its hub is at the junction of the presubiculum and retrosplenial cortex.”
   2. UncheckedBrain regions connected to one spot, at the presubiculum–retrosplenial cortex junction, form a circuit that includes over 95% of lesions causing amnesia.“Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia.”
   3. UncheckedThe extent to which a brain lesion overlaps a derived memory circuit is reported to predict memory scores in two separate patient datasets.“Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176).”