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Keyword: protein scaffolding ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Scaffolding protein functional sites using deep learning

   Wang, Lisanza, Juergens et al. · Science · 2022

   The paper describes two deep learning methods for building protein scaffolds around functional sites, and uses them to design several kinds of proteins, checked by computer and laboratory tests.

   Unchecked2 claims
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   1. UncheckedOne of two deep learning methods, "constrained hallucination", optimises sequences so their predicted structures contain a desired functional site.“The first approach, “constrained hallucination,” optimizes sequences such that their predicted structures contain the desired functional site.”
   2. UncheckedThe 'inpainting' method builds a protein scaffold around a functional site in one pass through a specially trained RoseTTAFold network.“The second approach, “inpainting,” starts from the functional site and fills in additional sequence and structure to create a viable protein scaffold in a single forward pass through a specifically trained RoseTTAFold network.”