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Keyword: protein sequence prediction ×Clear all

1 claim from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Bilingual language model for protein sequence and structure

   Heinzinger, Weißenow, Sánchez et al. · NAR Genomics and Bioinformatics · 2024

   The authors fine-tuned the protein language model ProtT5 to translate between amino acid sequences and Foldseek's 3Di structure alphabet, creating ProstT5, a single model covering both sequence and structure.

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   1. UncheckedA protein language model, ProstT5, improved structure-related predictions and derived 3Di structure tokens about a thousand times faster than before.“As a proof-of-concept for our novel approach, dubbed Protein ‘structure-sequence’ T5 (ProstT5), we showed improved performance for subsequent, structure-related prediction tasks, leading to three orders of magnitude speedup for deriving 3Di.”