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1,280 claims from 801 papers are on the record. 46 have been checked so far; the other 1,234 have no check with a result yet.

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Status: Unchecked ×Keyword: protein structure clustering ×Clear all

5 claims from 2 papers

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Clustering predicted structures at the scale of the known protein universe

   Barrio‐Hernandez, Yeo, Jänes et al. · Nature · 2023

   The authors built Foldseek cluster, a fast structure-alignment clustering method, and used it to group the AlphaFold database's predicted structures to study protein function and evolution.

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   1. UncheckedClustering the whole AlphaFold database gave 2.30 million multi-member structural clusters, 31% of which lack annotations and may be undescribed structures.“Using this method, we have clustered all of the structures in the AlphaFold database, identifying 2.30 million non-singleton structural clusters, of which 31% lack annotations representing probable previously undescribed structures.”
   2. UncheckedStructural clusters in the AlphaFold database that lack annotation tend to have few members, together covering only 4% of all proteins in the database.“Clusters without annotation tend to have few representatives covering only 4% of all proteins in the AlphaFold database.”

2. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   Clustering predicted structures at the scale of the known protein universe

   Barrio‐Hernandez, Yeo, Jänes et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2023

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   1. Unchecked“Using this method we have clustered all structures in AFDB, identifying 2.27M non-singleton structural clusters, of which 31% lack annotations representing likely novel structures.”
   2. Unchecked“Clusters without annotation tend to have few representatives covering only 4% of all proteins in the AFDB.”
   3. Unchecked“Evolutionary analysis suggests that most clusters are ancient in origin but 4% seem species specific, representing lower quality predictions or examples of de-novo gene birth.”