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Keyword: quaternary structure prediction ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   An atlas of protein homo-oligomerization across domains of life

   Schweke, Pačesa, Levin et al. · Cell · 2024

   The authors used AlphaFold2 to predict homo-oligomeric assemblies across four proteomes spanning the tree of life, giving a broad view of how proteins assemble into identical-subunit complexes.

   Unchecked2 claims
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   1. UncheckedPredictions suggest about 45% of one archaeal and one bacterial proteome, and 20% of two eukaryotic proteomes, form homomers.“Our results suggest that approximately 45% of an archaeal proteome and a bacterial proteome and 20% of two eukaryotic proteomes form homomers.”
   2. Unchecked“Finally, these datasets provide a structural context for interpreting disease mutations and reveal coiled-coil regions as major enablers of quaternary structure evolution in human.”