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Status: Unchecked Keyword: sequence design Clear all
2 claims from 1 paper
Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics
An all-atom protein generative model
Chu, Kim, Cheng et al. · Proceedings of the National Academy of Sciences · 2024
The paper presents Protpardelle, an all-atom diffusion model of protein structure that uses "superposition" states for sidechains, and reports on the quality of its designs and its potential for functional-motif scaffolding.
Unchecked2 claimsShow 2 claims
- UncheckedPaired with sequence design methods, the Protpardelle model can design a protein's all-atom structure and its amino acid sequence together.“When combined with sequence design methods, our model is able to codesign all-atom protein structure and sequence.”
- UncheckedProteins generated by the Protpardelle model score well on standard quality, diversity and novelty measures, and its sidechains mimic natural proteins' chemistry.“Generated proteins are of good quality under the typical quality, diversity, and novelty metrics, and sidechains reproduce the chemical features and behavior of natural proteins.”
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