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Status: Unchecked ×Keyword: structure-function relationship ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Protein Structure and Dynamics

   AlphaFold2 reveals commonalities and novelties in protein structure space for 21 model organisms

   Bordin, Sillitoe, Nallapareddy et al. · Communications Biology · 2023

   The authors classified confident AlphaFold2 models from 21 model organisms with a new tool, CATH-Assign, finding most fit existing superfamilies while some form putative novel ones and expand CATH.

   Unchecked2 claims
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   1. UncheckedOf about 370,000 confident AlphaFold2 models from 21 model organisms, 92% could be assigned to 3253 existing CATH protein domain superfamilies.“Of ~370,000 confident models, 92% can be assigned to 3253 superfamilies in our CATH domain superfamily classification.”
   2. UncheckedConfident AlphaFold2 models from 21 model organisms expand the CATH protein domain database by 67% and its unique global folds by 36%.“Although most models map to existing superfamilies, AF2 domains expand CATH by 67% and increases the number of unique ‘global’ folds by 36% and will provide valuable insights on structure function relationships.”