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Status: Unchecked ×Keyword: transcription factor binding sites ×Clear all

2 claims from 1 paper

1. Biochemistry, Genetics and Molecular Biology › Machine Learning in Bioinformatics

   Genome modeling and design across all domains of life with Evo 2

   Brixi, Durrant, Ku et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2025

   The paper introduces Evo 2, an open DNA foundation model trained on 9.3 trillion base pairs across all domains of life, which predicts variant effects, learns biological features and generates genome-scale sequences.

   Unchecked2 claims
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   1. UncheckedEvo 2 generates mitochondrial, prokaryotic and eukaryotic DNA sequences at genome scale that the authors report as more natural and coherent than earlier methods.“Beyond its predictive capabilities, Evo 2 generates mitochondrial, prokaryotic, and eukaryotic sequences at genome scale with greater naturalness and coherence than previous methods.”
   2. Unchecked“Guiding Evo 2 via inference-time search enables controllable generation of epigenomic structure, for which we demonstrate the first inference-time scaling results in biology.”