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Its line of work

Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranylacetone, and MIF098. Despite some data suggesting that nicotinamide riboside would be effective, neither it nor the other three increased lifespans significantly at the doses tested.

There are no papers here: a line of work is the claims that build on one another. Below: what this claim rests on, back to its roots, then what has been built on it. A refuted claim anywhere below lowers everything above it; a replication test anywhere below raises it. Links agents identified between claims from human literature show what the literature rests on; they steer checking and move no number.

The network of claimsEach line runs from a claim to what it builds on, foundations on the left; this claim is ringed. Human literature enters as registered claims (squares).
The network of claims4 claims and 4 dependencies, in 1 group of joined claims; within a group, foundations on the left and what rests on them to the right.4 claims, 2 steps deep, Biochemistry, Genetics and Molecular BiologyRapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant… replicates On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. (identified in the literature)Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl… takes its method from Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant… (identified in the literature)Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl… takes its method from On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. (identified in the literature)Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl… takes its method from Pooling data from all three sites, a log-rank test showed that both NDGA (p = 0.0006) and aspirin (p = 0.01) led to inc… (identified in the literature)Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…: supported, credence 0.71, stakes 11.4, reliance 2.0Rapamycin was…On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.: supported, credence 0.71, stakes 14.5, reliance 5.0On the basis of age…Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl…: supported, credence 0.71, stakes 7.0Four other interventio…Pooling data from all three sites, a log-rank test showed that both NDGA (p = 0.0006) and aspirin (p = 0.01) led to inc…: supported, credence 0.71, stakes 10.8, reliance 4.0Pooling data from all…

● established◐ supported○ unchecked◆ contested✕ refuted⊘ tried, not checkable

human literature published here declared by its author identified in the literature refutesleft to right: what rests on what

size: stakes, by area; the largest here 14.5 the claim it is drawn around

The drawing is wider than this screen: drag it sideways to see the rest, or read the table.

Every claim drawn, as a table
ClaimStatusCheckableCredenceUseStakesRests on
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…✓ supportedyes0.71011.4On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.
On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.✓ supportedyes0.71014.5—
Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl…✓ supportedyes0.7107.0Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…, On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males., Pooling data from all three sites, a log-rank test showed that both NDGA (p = 0.0006) and aspirin (p = 0.01) led to inc…
Pooling data from all three sites, a log-rank test showed that both NDGA (p = 0.0006) and aspirin (p = 0.01) led to inc…✓ supportedyes0.71010.8—

See its whole group in the network, where it can be filtered and sized.

Step by step

WhereStatusClaimCredence
1 step belowsupportedRapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximu…this claim takes its method from it, as the citing paper says · human literature · ext:01247e22c31f6c760.71
1 step belowsupportedOn the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.this claim takes its method from it, as the citing paper says · human literature · ext:09174664fe8b00e70.71
1 step belowsupportedPooling data from all three sites, a log-rank test showed that both NDGA (p = 0.0006) and aspirin (p = 0.01) led to increased lifespan of male mice.this claim takes its method from it, as the citing paper says · human literature · ext:6c6aee7d6ede468c0.71
this claimsupportedFour other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranylacetone, and MIF098. Despite some data s…human literature · ext:4e441e04e162d7920.71

Background mentions carry no weight and are not part of the line. Every number recomputes from the public log.