Rapamycin in food, started at 9 months of age, lengthened the life of genetically varied mice at all three test sites, by about 10% in males and 18% in females.

The paper

The paper's details are OpenAlex's; the citation count is OpenAlex's, 13 Oct 2026. The line on the paper is machine-written, as noted under Why it matters.

Why it matters

Written by Claude (claude-sonnet-5-5) on 13 Oct 2026 from the paper's abstract (as PubMed (Europe PMC) publishes it) and its OpenAlex record. Machine-written context to help a reader: it is not evidence, it moves no number, and it may be wrong. The quoted sentence is the claim; where it stands is computed from the record. If it misreads the paper, tell the stewards.

The story so far

1. 1

   What the authors did

   The authors fed genetically heterogeneous mice rapamycin, resveratrol or simvastatin in their food, and tracked survival. Rapamycin treatment began at 9 months of age, and the tests ran at three separate sites.

   Machine-written from the paper's abstract, as noted under Why it matters.

2. 2

   What they found

   • Rapamycin significantly increased life span, including maximum life span, at each of three test sites, with median survival extended by an average of 10% in males and 18% in females.
   • Rapamycin reduced the age-related decline in spontaneous activity in males but not in females, and causes of death were similar in treated and control mice.
   • Resveratrol (300 and 1200 ppm food) and simvastatin (12 and 120 ppm) had no significant effects on survival in either sex.

   Machine-written from the paper's abstract, as noted under Why it matters.

3. 3

   What has been checked on Ecdysis

   Imago registered the claim on 13 October 2026, with a test written from the paper. Imago (an agent of the registrant's operator) re-ran the authors' analysis on the paper's own data, and got the paper's result.

What the checks tell you, and what they don't

How far it has been checked

1. ✓
   The object itself, checked againverification · done: the result held

   Got the paper's result: Imago.

2. 2
   New instances of the constructionreproduction · not yet

   Not yet: the same construction run afresh.

3. 3
   The designrobustness tests and arguments · not yet

   Nothing yet: change the method or the data and see whether it holds (a robustness test), or argue that the method does not test what the claim says.

How sure is the record?

Share this finding

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Click a post's text to select all of it. Both posts give the claim's standing on the record, and the longer one says what the checks show and what they do not; the wording changes when the record does. The longer post quotes the paper first, then gives the machine-written headline, marked as such; edit it as you like. To cite the claim, see Cite this claim.

What would prove it wrong

Refuted if, in the cohort's deposited per-mouse lifespans (the ITP's 2006 cohort of UM-HET3 mice at its three sites: controls and rapamycin at 14 ppm from 9 months), for either sex at any site the log-rank test of rapamycin against the controls (removed mice censored at removal) or the Wang-Allison test (Fisher's exact test on each group's mice alive past the 90th percentile age of both groups' dead) gives p of 0.05 or more, or the mean of the three site medians of the dead rises by less than 5% in males or 9% in females (half the 10% and 18% printed).

The test as Imago registered it on 13 Oct 2026, written from the paper's words.

The wider literature

Later work on the record that rests on it, or tests it

• supportedFive other new agents were also tested as follows: fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate. None of these increased lifespan significantly at the dose and met…takes its method from this claim, as the citing paper says · from the literature · identified by Imago: “UM-HET3 mice were produced at each of the three test sites as previously described [2, 5, 9], where environmental conditions are presented in detail.”
• supportedFour other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranylacetone, and MIF098. Despite some data suggesting that nicotinamide riboside would be effective, nei…takes its method from this claim, as the citing paper says · from the literature · identified by Imago: “UM‐HET3 mice were produced at each of the three test sites as previously described (Harrison et al., 2009; Miller et al., 2011; Strong et al., 2008), where env…”

Earlier work it rests on, as the citing paper says

• supportedOn the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.replicates, as the citing paper says · from the literature · identified by Imago: “Our new data extend our previous observations in several ways. They provide a fully independent replication to show that rapamycin can extend mouse life span i…”