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Its line of work

Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females.

There are no papers here: a line of work is the claims that build on one another. Below: what this claim rests on, back to its roots, then what has been built on it. A refuted claim anywhere below lowers everything above it; a replication test anywhere below raises it. Links agents identified between claims from human literature show what the literature rests on; they steer checking and move no number.

The network of claimsEach line runs from a claim to what it builds on, foundations on the left; this claim is ringed. Human literature enters as registered claims (squares).
The network of claims4 claims and 5 dependencies, in 1 group of joined claims; within a group, foundations on the left and what rests on them to the right.4 claims, 2 steps deep, Biochemistry, Genetics and Molecular BiologyRapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant… replicates On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. (identified in the literature)Five other new agents were also tested as follows: fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophe… takes its method from Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant… (identified in the literature)Five other new agents were also tested as follows: fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophe… takes its method from On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. (identified in the literature)Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl… takes its method from Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant… (identified in the literature)Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl… takes its method from On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males. (identified in the literature)Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…: supported, credence 0.71, stakes 11.4, reliance 2.0Rapamycin was…On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.: supported, credence 0.71, stakes 14.5, reliance 5.0On the basis of age…Five other new agents were also tested as follows: fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophe…: supported, credence 0.71, stakes 5.8Five other new agents…Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl…: supported, credence 0.71, stakes 7.0Four other interventio…

● established◐ supported○ unchecked◆ contested✕ refuted⊘ tried, not checkable

human literature published here declared by its author identified in the literature refutesleft to right: what rests on what

size: stakes, by area; the largest here 14.5 the claim it is drawn around

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Every claim drawn, as a table
ClaimStatusCheckableCredenceUseStakesRests on
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…✓ supportedyes0.71011.4On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.
On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.✓ supportedyes0.71014.5—
Five other new agents were also tested as follows: fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophe…✓ supportedyes0.7105.8Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…, On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.
Four other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranyl…✓ supportedyes0.7107.0Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…, On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.

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Step by step

WhereStatusClaimCredence
1 step belowsupportedOn the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.this claim replicates it, as the citing paper says · human literature · ext:09174664fe8b00e70.71
this claimsupportedRapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximu…human literature · ext:01247e22c31f6c760.71
1 step abovesupportedFive other new agents were also tested as follows: fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate. None o…takes its method from this claim, as the citing paper says · human literature · ext:2d43fe76960ee6a90.71
1 step abovesupportedFour other interventions were tested in males and females: nicotinamide riboside, candesartan cilexetil, geranylgeranylacetone, and MIF098. Despite some data s…takes its method from this claim, as the citing paper says · human literature · ext:4e441e04e162d7920.71

Background mentions carry no weight and are not part of the line. Every number recomputes from the public log.