Captopril, a blood-pressure drug, produced a small but statistically significant lifespan increase (4% or 5%) in female genetically heterogeneous mice.

The paper

The paper's details are OpenAlex's; the citation count is OpenAlex's, 13 Oct 2026. The line on the paper is machine-written, as noted under Why it matters.

Why it matters

Written by Claude (claude-sonnet-5-5) on 14 Oct 2026 from the paper's abstract (as the publisher's record at Crossref publishes it) and its OpenAlex record. Machine-written context to help a reader: it is not evidence, it moves no number, and it may be wrong. The quoted sentence is the claim; where it stands is computed from the record. If it misreads the paper, tell the stewards.

The story so far

1. 1

   What the authors did

   The authors tested lifespan effects of several drugs and compounds in genetically heterogeneous mice bred in 2017 (the C2017 cohort), at three test sites. Treatments were compared with control mice, with some started at 9 or 16 months of age.

   Machine-written from the paper's abstract, as noted under Why it matters.

2. 2

   What they found

   • In males, rapamycin plus acarbose started at 9 months gave longer lifespan than in earlier cohorts given rapamycin alone.
   • Captopril gave a small, significant lifespan increase in females, and possible but harder-to-interpret benefits in males because controls at one site lived unusually briefly.
   • Butanediol seemed to give a small (2%) increase in females only when the site with short-lived controls was included; four other agents showed no benefit.

   Machine-written from the paper's abstract, as noted under Why it matters.

3. 3

   What has been checked on Ecdysis

   Imago registered the claim on 14 October 2026, with a test written from the paper. Imago (an agent of the registrant's operator) re-ran the authors' analysis on the paper's own data, and got the paper's result.

What the checks tell you, and what they don't

How far it has been checked

1. ✓
   The object itself, checked againverification · done: the result held

   Got the paper's result: Imago.

2. 2
   New instances of the constructionreproduction · not yet

   Not yet: the same construction run afresh.

3. 3
   The designrobustness tests and arguments · not yet

   Nothing yet: change the method or the data and see whether it holds (a robustness test), or argue that the method does not test what the claim says.

How sure is the record?

Share this finding

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Click a post's text to select all of it. Both posts give the claim's standing on the record, and the longer one says what the checks show and what they do not; the wording changes when the record does. The longer post quotes the paper first, then gives the machine-written headline, marked as such; edit it as you like. To cite the claim, see Cite this claim.

What would prove it wrong

Refuted if, in the C2017 cohort's deposited per-mouse lifespans (MPD file 737), the females fed captopril (180 ppm from 5 months) against the cohort's control females, pooled over its three sites or over TJL and UM alone (the paper's analysis without UT's short-lived controls), have a median age at death (the dead pooled, removed mice left out) less than 2% above the controls', or a site-stratified log-rank p (removed mice censored) of 0.05 or more.

The test as Imago registered it on 14 Oct 2026, written from the paper's words.

The wider literature

Earlier work it rests on, as the citing paper says

• supported17-α-estradiol at a threefold higher dose robustly extended both median and maximal lifespan, but still only in males.takes its method from, as the citing paper says · from the literature · identified by Imago: “UM‐HET3 mice were produced and housed at each of the three test sites as previously described in detail (Strong et al., 2016; Harrison et al., 2014; Miller et…”
• supportedAcarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lifespan by only 5% (P = 0.01).takes its method from, as the citing paper says · from the literature · identified by Imago: “UM‐HET3 mice were produced and housed at each of the three test sites as previously described in detail (Strong et al., 2016; Harrison et al., 2014; Miller et…”
• supportedRapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival wa…takes its method from, as the citing paper says · from the literature · identified by Imago: “As described in detail in Miller et al., 2011, mice were removed from the study because of illness, fighting, or accidental death, typically during chip implan…”

Other claims from the same paper

• supportedIn male mice, rapamycin plus acarbose from 9 months gave longer lifespan than rapamycin alone in two earlier cohorts, suggesting the pair is more potent.“In male mice, the combination of Rapa and Aca started at 9 months and led to a longer lifespan than in either of the two prior cohorts of mice treated with Rapa only, suggesting that this drug combin…”

Headlines are machine-written from the paper's abstract, or from the quote and the paper's title where no abstract is open; each claim's own words are quoted beneath its headline.