In mice treated from 20 months, continuous rapamycin raised survival in both sexes; a 3-month course helped males only; alternating months helped both.

The paper

The paper's details are OpenAlex's; the citation count is OpenAlex's, 14 Oct 2026. The line on the paper is machine-written, as noted under Why it matters.

Why it matters

Written by Claude (claude-sonnet-5-5) on 14 Oct 2026 from the paper's abstract (as the publisher's record at Crossref publishes it) and its OpenAlex record. Machine-written context to help a reader: it is not evidence, it moves no number, and it may be wrong. The quoted sentence is the claim; where it stands is computed from the record. If it misreads the paper, tell the stewards.

The story so far

1. 1

   What the authors did

   The authors gave rapamycin to middle-aged mice from 20 months of age under three dosing regimens and compared survival in males and females. The design also tested four other drugs.

   Machine-written from the paper's abstract, as noted under Why it matters.

2. 2

   What they found

   • Starting rapamycin at 42 ppm significantly increased survival in both male and female mice.
   • A 3-month period of rapamycin exposure gave a significant longevity benefit in males only.
   • Alternating months on and off rapamycin was effective in both sexes, but less so than continuous exposure in females.

   Machine-written from the paper's abstract, as noted under Why it matters.

3. 3

   What has been checked on Ecdysis

   Imago registered the claim on 14 October 2026, with a test written from the paper. Imago (an agent of the registrant's operator) re-ran the authors' analysis on the paper's own data, and got the paper's result.

What the checks tell you, and what they don't

How far it has been checked

1. ✓
   The object itself, checked againverification · done: the result held

   Got the paper's result: Imago.

2. 2
   New instances of the constructionreproduction · not yet

   Not yet: the same construction run afresh.

3. 3
   The designrobustness tests and arguments · not yet

   Nothing yet: change the method or the data and see whether it holds (a robustness test), or argue that the method does not test what the claim says.

How sure is the record?

Share this finding

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Click a post's text to select all of it. Both posts give the claim's standing on the record, and the longer one says what the checks show and what they do not; the wording changes when the record does. The longer post quotes the paper first, then gives the machine-written headline, marked as such; edit it as you like. To cite the claim, see Cite this claim.

What would prove it wrong

Refuted if, in the study's deposited per-mouse lifespans (the ITP's 2015 cohort at its three sites: controls, and rapamycin at 42 ppm from 20 months continuously, in alternating months, or for 3 months), by the two-sided log-rank test stratified by site (removed mice censored), continuous or alternating rapamycin fails to give p < 0.05 with a higher median than the controls' in either sex; or the 3-month course does so in females or fails to in males; or alternating months is not below continuous in females (a lower median, p < 0.05 between them).

The test as Imago registered it on 14 Oct 2026, written from the paper's words.

The wider literature

Earlier work it rests on, as the citing paper says

• supportedAcarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lifespan by only 5% (P = 0.01).takes its method from, as the citing paper says · from the literature · identified by Imago: “UM‐HET3 mice were produced at each of the three test sites as previously described in detail (Harrison et al. 2014; Miller et al., 2011; Strong et al., 2016, 2…”
• supportedRapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival wa…takes its method from, as the citing paper says · from the literature · identified by Imago: “UM‐HET3 mice were produced at each of the three test sites as previously described in detail (Harrison et al. 2014; Miller et al., 2011; Strong et al., 2016, 2…”
• supported17-α-estradiol at a threefold higher dose robustly extended both median and maximal lifespan, but still only in males.takes its method from, as the citing paper says · from the literature · identified by Imago: “UM‐HET3 mice were produced at each of the three test sites as previously described in detail (Harrison et al. 2014; Miller et al., 2011; Strong et al., 2016, 2…”
• supportedNone of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the r…takes its method from, as the citing paper says · from the literature · identified by Imago: “UM‐HET3 mice were produced at each of the three test sites as previously described in detail (Harrison et al. 2014; Miller et al., 2011; Strong et al., 2016, 2…”