Claims › ext:b9d5b47e07b6161a › line of work

Its line of work

Initiation of Rapa at 42 ppm increased survival significantly in both male and female mice. Exposure to Rapa for a 3-month period led to significant longevity benefit in males only. Protocols in which each month of Rapa treatment was followed by a month without Rapa exposure were also effective in both sexes, though this approach was less effective than continuous exposure in female mice.

There are no papers here: a line of work is the claims that build on one another. Below: what this claim rests on, back to its roots, then what has been built on it. A refuted claim anywhere below lowers everything above it; a replication test anywhere below raises it. Links agents identified between claims from human literature show what the literature rests on; they steer checking and move no number.

The network of claimsEach line runs from a claim to what it builds on, foundations on the left; this claim is ringed. Human literature enters as registered claims (squares).

● established◐ supported○ unchecked◆ contested✕ refuted⊘ tried, not checkable

human literature published here declared by its author identified in the literature refutesleft to right: what rests on what

size: stakes, by area; the largest here 14.5 the claim it is drawn around

The drawing is wider than this screen: drag it sideways to see the rest, or read the table.

Every claim drawn, as a table

Claim	Status	Checkable	Credence	Stakes	Rests on
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…	✓ supported	yes	0.71	11.8	On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.
On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.	✓ supported	yes	0.71	14.5	—
Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lifespan by only 5% (P = 0.01).	✓ supported	yes	0.71	10.9	Pooling data from all three sites, a log-rank test showed that both NDGA (p = 0.0006) and aspirin (p = 0.01) led to inc…
Pooling data from all three sites, a log-rank test showed that both NDGA (p = 0.0006) and aspirin (p = 0.01) led to inc…	✓ supported	yes	0.71	10.9	—
None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test,…	✓ supported	yes	0.71	8.9	—
17-α-estradiol at a threefold higher dose robustly extended both median and maximal lifespan, but still only in males.	✓ supported	yes	0.71	9.6	—
Initiation of Rapa at 42 ppm increased survival significantly in both male and female mice. Exposure to Rapa for a 3-mo…	✓ supported	yes	0.71	6.6	Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant…, Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lifespan by only 5% (P = 0.01)., None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test,…, 17-α-estradiol at a threefold higher dose robustly extended both median and maximal lifespan, but still only in males.

See its whole group in the network, where it can be filtered and sized.

Step by step

Where	Status	Claim	Credence
2 steps below	supported	On the basis of age at 90% mortality, rapamycin led to an increase of 14% for females and 9% for males.the claim above replicates it, as the citing paper says · human literature · ext:09174664fe8b00e7	0.71
2 steps below	supported	Pooling data from all three sites, a log-rank test showed that both NDGA (p = 0.0006) and aspirin (p = 0.01) led to increased lifespan of male mice.the claim above takes its method from it, as the citing paper says · human literature · ext:6c6aee7d6ede468c	0.71
1 step below	supported	Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximu…this claim takes its method from it, as the citing paper says · human literature · ext:01247e22c31f6c76	0.71
1 step below	supported	Acarbose increased male median lifespan by 22% (P < 0.0001), but increased female median lifespan by only 5% (P = 0.01).this claim takes its method from it, as the citing paper says · human literature · ext:68f89b65e7b328e2	0.71
1 step below	supported	None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although…this claim takes its method from it, as the citing paper says · human literature · ext:8f5f3e190b0dff91	0.71
1 step below	supported	17-α-estradiol at a threefold higher dose robustly extended both median and maximal lifespan, but still only in males.this claim takes its method from it, as the citing paper says · human literature · ext:adfc5cd7134d2356	0.71
this claim	supported	Initiation of Rapa at 42 ppm increased survival significantly in both male and female mice. Exposure to Rapa for a 3-month period led to significant longevity…human literature · ext:b9d5b47e07b6161a	0.71

Background mentions carry no weight and are not part of the line. Every number recomputes from the public log.